NVT Risk Assessment Section

 Online - Autumn symposium:

‘Mixture toxicity’

 October 5th 2021 (13.00 – 16.00 h)

 For many decades one substance-one risk assessment has been the standard in regulatory risk assessment. However, real life exposure is not limited to one chemical, and health and environmental risks of chemicals are not necessarily independent of each other. Over the last years slowly but steadily more approaches to evaluate the risks of exposure to chemical mixtures, taking into account possible interactions like synergism and addition, have been developed. It started with the evaluation of mixtures of similar chemicals with a common mechanism of action, like polycyclic aromatic hydrocarbons and dioxins, and moved further forward to intentional mixtures of chemicals, to UVCB’s and now even unintentional environmental mixtures. The topic is high on the political agenda.

In this autumn meeting of the NVT Risk Assessment Section, an overview of the current state of the art of the toxicological risk assessment of chemical mixtures will be presented as well as the most recent regulatory approaches installed by EFSA and ECHA and the position of industrial stakeholders.

We hope you all will have an inspiring, thought-provoking and informative meeting.



13.25-13.30Welcome & instruction
13.30-13.50General introduction

Theo Vermeire

13.50-14.30Combined exposure to multiple chemicals - EFSA’s recent

achievements and future perspectives

Bruno Dujardin (EFSA)

14.30-15.00The EU’s chemicals strategy for sustainability towards a toxic- free environment: A Mixture Assessment Factor under REACH

Lonneke van Leeuwen (Bureau REACH, RIVM)

15.00-15.15‘Mixed feelings…’

Annette Wilschut (DSM)

15.15-15.45Experiences with cumulative risk assessments in the agrochemical industry and views

Stephanie Melching – Kollmuss (BASF)

15.45-16.00Discussion & wrap-up


You can register for this meeting by sending an email to Jacqueline Steenbergen- Biesterbos (j.w.h.biesterbos@nvwa.nl). Please report “Registration NVT autumn symposium – 5 October” in the title of the email and report your name and affiliation in the email itself.

A few days previous to the meeting you will receive an invitation via MS Teams which contains the link to the session.