{"id":4816,"date":"2020-01-10T12:43:23","date_gmt":"2020-01-10T12:43:23","guid":{"rendered":"https:\/\/toxicologie.nl\/the-revolution-of-toxicological-models-how-to-address-safety-in-target-species\/"},"modified":"2021-02-23T09:20:19","modified_gmt":"2021-02-23T09:20:19","slug":"the-revolution-of-toxicological-models-how-to-address-safety-in-target-species","status":"publish","type":"post","link":"https:\/\/toxicologie.nl\/en\/the-revolution-of-toxicological-models-how-to-address-safety-in-target-species\/","title":{"rendered":"The (r)evolution of toxicological models \u2013 how to address safety in target species"},"content":{"rendered":"<p>As toxicologists we aim to assess the safety of substances in the species<br \/>\nwe wish to protect, *i.e.* the target species. However, often we cannot<br \/>\nsimply conduct toxicity testing in the target species itself. This forces<br \/>\nus to use model systems, traditionally animal models and nowadays also *in<br \/>\nsilico* and *in vitro *models. Obviously, these models are a proxy of the<br \/>\ntruth and have their own pros and cons. While animal models have many<br \/>\nadvantages, there is an urgent need for replacements. The Dutch government<br \/>\nstrongly promotes the reduction of animal testing. In addition, last<br \/>\nSeptember, the U.S. EPA announced that they will stop conducting or funding<br \/>\nmammalian animal studies by 2035. During the upcoming NVT Annual Meeting,<br \/>\nwe will talk about safety assessment and toxicity testing in target species<br \/>\nand discuss the challenges that we face in applying alternative models into<br \/>\n(regulatory) practice. What are the best models for the target species of<br \/>\ninterest? Can we measure within the target species itself? When do we have<br \/>\nsufficient information to predict safety in target species? How do we<br \/>\nimplement innovative and predictive models in regulatory risk assessment?<br \/>\nJoin our discussion on these important issues during the online NVT Annual Meeting<br \/>\non *June 9-10, 2020<\/p>\n<p>Please visit the website for more information.<br \/>\n<a href=\"http:\/\/www.toxicologie.nl\/meeting2021\">www.toxicologie.nl\/meeting2021<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>As toxicologists we aim to assess the safety of substances in the species we wish to protect, *i.e.* the target species. However, often we cannot simply conduct toxicity testing in the target species itself. This forces us to use model systems, traditionally animal models and nowadays also *in silico* and *in vitro *models. Obviously, these [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":881,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[40,41],"tags":[],"class_list":["post-4816","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-featured-news","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The (r)evolution of toxicological models \u2013 how to address safety in target species - Nederlandse Vereniging voor Toxicologie<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/toxicologie.nl\/en\/the-revolution-of-toxicological-models-how-to-address-safety-in-target-species\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The (r)evolution of toxicological models \u2013 how to address safety in target species - Nederlandse Vereniging voor Toxicologie\" \/>\n<meta property=\"og:description\" content=\"As toxicologists we aim to assess the safety of substances in the species we wish to protect, *i.e.* the target species. However, often we cannot simply conduct toxicity testing in the target species itself. This forces us to use model systems, traditionally animal models and nowadays also *in silico* and *in vitro *models. 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