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February 6, 2018 1:00 pm UTC-5

Organized By

Society of Toxicology

The sheer numbers of chemicals already in commerce and the pace, at which new chemicals are being developed and used, have outpaced our ability to assess their safety using the traditional animal-reliant test methods. This has resulted in emergence of novel toxicity testing strategies involving in vitro and in silico models as alternative to animal testing. However, unless based on the mechanistic knowledge, the alternative testing strategies offer little to alleviate the burden placed on toxicologists to complete the human health risk assessment of these chemicals in a timely and effective manner.

Adverse Outcome Pathways (AOPs) is a framework that enables structured and simple representation of mechanistic knowledge in the form of causally linked biological events at various levels of biological organisation.

Diverse classes of nanomaterials exhibiting a wide array of physical-chemical properties are currently in commercial use and are known to exert toxicological effects in experimental animals. However, an integrated framework for the human health risk assessment of nanomaterials has yet to be established. In this presentation, how construction of AOPs can advance risk assessment of nanomaterials will be discussed. Specifically, the presentation will summarise various AOPs that are currently addressing nanomaterial-induced adverse outcomes, role of ‘omics’ in the development of AOPs and finally, present a case study that is currently investigating their utility in risk assessment and risk categorisation of nanomaterials.

Overall, the webinar (~45 mins duration) will highlight and present the findings on 'Adverse Outcome Pathway Framework in Respiratory Toxicology' with emphasis on inhalation toxicology. The webinar is unique and will serve as a forum for novel approaches related to inhalation toxicology, foster integration of other scientific disciplines and specialties, promote integration and transformation of exposure science in toxicology, understand toxicological impacts on public health, and initiate discussion on environmental health issues for policy regulation. A broad range of society members will be benefited from this webinar.

Irfan Rahman, PhD Professor, University of Rochester, Rochester, NY
Matthew Campen, PhD, Professor, University of New Mexico, Albuquerque, NM

Andrea De Vizcaya-Ruiz, PhD

Registration is Required for this event.