Held on December 13, 2016
Speaker: Alys Bradley BSc, BVSc, MAnimSc, DipRCPath, FRIPH, MRCVS, FRCPath, FIATP, RCVS Specialist in Veterinary Pathology
Charles River Laboratories Edinburgh
This webinar covered a variety of background findings that can be commonly seen in toxicity studies with rabbits.
Held on November 5, 2015
Speaker: Jan Willem van der Laan, Chair Safety Working Party (human), European Medicines Agency
Senior Assessor Pharmacology-Toxicology, Medicines Evaluation Board, The Netherlands
Safety assessment of human pharmaceuticals is a multidisciplinary challenge. Pharmacologists are involved in the discovery to find a drug for the intended target, and to check for off-target effects. General toxicologists, pharmacokineticists and pathologists are working together to describe the consequences of these effects in animal models. Translational steps are important for the prediction of the safety of the compound in humans. Important safety aspects are carcinogenicity, reproductive toxicity and immunotoxicity. All these areas have an important histopathological component, and high quality reports are essential in the evaluation of these aspects. The webinar will focus on Carcinogenicity testing of human pharmaceuticals, and highlight discussions that are ongoing, especially in relation to the International Conference on Harmonization.