Herstart in Linked- groep van arbeidstoxicologen
Linked-in is een online sociaal netwerk, dat gericht is op vakmensen. Het belangrijkste doel van de website is om leden gebruik te laten maken van elkaars netwerk van werkcontacten. Linked-in heeft ook specifieke interesse groepen, waarvoor je je kunt aanmelden.
In 2011 dachten we dat de tijd al rijp was voor een Linked-in groep van Nederlandse Arbeidstoxicologen + verwante disciplines. Maar we waren duidelijk te vroeg. De Linked-in groep van de sectie Arbeidstoxicologie van de Nederlandse Vereniging voor Toxicologie (NVT) leed een kwijnend bestaan.
Inmiddels is Linked-in verder gegroeid (en intussen overgenomen door Microsoft). Wij, als sectiebestuur, geloven in de waarde van een dergelijk groep. Om informatie uit te wisselen, te overleggen, te discussiëren, gedachten te droppen, etc.
We gaan trekken aan een herstart van deze groep. Via extra publiciteit hopen we de groep leven in te blazen. Om een levensvatbare groep te hebben denken we dat minimaal 50 leden nodig zijn, maar liever meer. Dus meld je aan. Je bent van harte welkom! Het standaardaccount van Linked-in is overigens gratis.

Webadres https://www.linkedin.com/groups/3958060

Frans Jongeneelen, beheerder linked-in groep van de sectie Arbeidstoxicologie van de NVT,

De presentaties van het middagsymposium van 9 maart 2017, over de beoordeling van de risico's van blootstelling aan mengels van stoffen op het werk, zijn nu beschikbaar.

Op 9 maart 2017 organiseert de sectie Arbeidstoxicologie een middagsymposium rond het thema "Health risk assessment bij beroepsmatige blootstelling aan mengsels en meerdere stoffen tegelijk". Zie voor meer informatie de uitnodiging.

On 3 and 4 october 2016, the FIGON organizes the Dutch Medicines Days (http://www.figondmd.nl/). The section Pharmaceutical Toxicology Section will organize a symposium on 3 october from 09:00 to 11:00 titled:

Integration of adverse outcome pathways, humanbased systems toxicology and exposure modelling in drug safety assessment

The Programme:

The ASAT Knowledge base data infrastructure: applications towards drug and chemical safety assessment.

Dr. Rob Stierum (Heading the applied systems toxicology at TNO)

Biokinetic modelling to predict cholestatic effects of drugs.
Dr. Sylvia Notenboom (Postdoc, Groningen University) and Dr. Karl Weigand (Postdoc, Radboudumc)

Mechanism Based Human Drug Disposition and Safety Assessment; A Pharma Perspective.
Dr. Mario Monshouwer (Senior Director and EU Head Pharmacokinetics, Dynamics & Metabolism, Johnson & Johnson, Beerse, Belgium)

Derailment of TNFα signaling in drug-induced liver injury
Suzanna Huppelschoten, M.Sc. (Leiden Academic Centre for Drug Research)

The business meeting of the section of Pharmaceutical toxicology was held during the first half of the lunch break of the spring symposium the 24th of March. The minutes of the 2015 meeting were briefly discussed, followed by a review of the activities in 2015: our lustrum symposium, and the contribution to the Dutch Medicines Days. The presentation of the Business meeting can be found below as an attachment to this post.

It was announced during the business meeting that Bob van de Water resigned as board member. We would like to thank him for his valued contributions to the section of Pharmaceutical Toxicology throughout the years. As his successor, Erik Danen was proposed. As there were no objections from the members of the section, we are happy to announce that Erik will be our new board member.


Reproductive Toxicology and Pharmaceutical Toxicology spring symposium

On the 24th of March 2016, the sections on Reproductive Toxicology and Pharmaceutical Toxicology organized a spring symposium entitled: ‘Pediatric drug development: a field in maturation’.

The invited speakers shared an overview of the latest insights on risk assessment of pediatric drugs from various perspectives. After a word of welcome, Saskia de Wildt kicked off the program with her presentation ‘Developmental Pharmacology: setting the stage’. Of the existing drugs on the market, there are still few drugs that are investigated for children. This has resulted in a diversity of dose recommendations for children through the years. In the Dutch Pediatric Formulary, the diverse dose recommendations have been combined in a single uniform dosing guideline. In the past, fatalities have occurred with ‘adult’ drugs in the pediatric patient population. Exposure might be diff erent in children, e.g. due to the ontogeny of the metabolizing enzymes and transporters, distribution volume, organ development. In clinical practice, a way to determine clinical doses for children without the supporting juvenile toxicity data has been established, assuming that when similar exposures are reached in children this will result in similar clinical efficacy.

To address some of these concerns, juvenile animal studies are conducted, as the second speaker Jan Willem van der Laan explained. The studies are conducted according to regional guidelines. In the form of the ICH S11 Guideline, an international harmonisation is on its way. The impact of the juvenile animal studies and need for harmonisation is illustrated by an overview of anti-cancer drug development for children. In half of the studies new target organ toxicities were observed in juvenile animals. The exposure levels in the juvenile animals were often higher than in the adults, which may result in toxicities at lower dose levels. Species selection, dose regimen, dose-range finding studies, dose adaptation and age at start of dosing as well as dose duration are important aspects to consider.

Illustrative of the need to understand the pediatric-specific pharmacodynamic (PD) and pharmacokinetic (PK) properties of a specifi c pharmaceutical compound was the presentation provided by Catherijne Knibbe. In clinical practice, drugs are often dosed on a mg/kg basis. As pediatric patients can have a higher clearance of the drug/kg body weight, higher dose levels might be required in the pediatric age category for the desired PD effect. Population PK-PD modelling can help to predict the dose levels required in the pediatric population, needed to achieve the desired PD effect. This method allows for few samples per individual, while more individuals are needed. Individualized dosing guidelines for specific drugs can be established, while for compounds metabolized through the same pathways a ‘system’ approach could be envisioned.

The meeting continued (after a lunch break) with real-life examples presented by Graham Bailey. As the title of his presentation mentioned: expect the unexpected when conducting non-clinical juvenile animal studies. To list just some of the discussion points when designing a juvenile animal study: the age of the animals at the start of dosing should be representative of the relative developmental stage of the intended pediatric clinical population. Making a study more complicated rarely makes interpretation easier. As mentioned by previous speakers, the ontogeny of the drug metabolizing enzymes and transporters should be taken into accountincluding species differences. Don’t forget that guidelines should be considered as just one way of achieving an objective, they should never be followed rigidly if there is a good scientific justification not to.

But how to we deal with pharmaceuticals for the pediatric population from a quality perspective? Diana van Riet explained how adequate product quality relates to chemical quality, pharmaceutical quality, usability including patient acceptability, and user instruction. Assessment of child and parent preference and acceptability of different formulations (from tablet to liquid) has revealed that historical assumptions are not always accurate. Further, the excipients used in the adult formulation are not always appropriate for use in the pediatric population due to safety concerns. The European Paediatric Formulation Initiative (EuPFI) Safety & Toxicity of Excipients for Paediatric (STEP) initiative is useful source for information on safety of specific excipients. (www.eupfi.org).

Once on the market, pharmaceuticals are carefully monitored for potential side eff ects. This pharmacovigilance, e.g. the monitoring of safety of pharmaceuticals after authorisation, was further detailed by Boukje Raemaekers. Information provided to the Netherlands Pharmacovigilance Centre (Lareb; www.lareb.nl) can be in the form of spontaneous reports of suspected adverse drug reactions from either healthcare professionals or consumers. On the label of medicines, it is mentioned that side eff ects can be reported at Lareb. After careful assessment, signals of adverse drug reactions might result in regulatory actions, Dear Healthcare Professional (DHCP) letters, product information updates and/or educational materials.

Overall, the day as organised by the sections on Reproductive Toxicology and Pharmaceutical Toxicology provided an overview of pediatric medicines, from the view of the health care professional, researcher, up to the regulator. Furthermore, they provided food for thought, like what should be the focus of the juvenile toxicity testing: the changing pharmacodynamic target during development, or the differences in exposure between children and adults; PD versus PK. This was clearly visible from the lively discussions between the participants during the drinks at the end of the day.




Bestuur van de sectie

Remi Laane (KNCV)

Chiel Jonker (KNCV) 

John Parsons (KNCV)

Vertegenwoordiger NVT bestuur:
Evelyn H.W. Heugens (NVT) 

Marie-Élène Boivin (NVT)
Harm G. van der Geest (NVT) 
Willem de Lange (KNCV)
Gorgias Meijers (KNCV) 
Heike Schmitt (NVT)
Ingrid Sterenborg (NVT)

Meer informatie over de sectie en haar activiteiten kunt u hier vinden. 

De sectie Milieutoxicologie is in 1982 opgericht. De sectie heeft als doelstelling het bevorderen van wetenschappelijk onderzoek en onderwijs in de milieutoxicologie. Daarnaast zet zij zich in om de toepassing van milieutoxicologisch onderzoek te bevorderen ten behoeve van de instandhouding en verbetering van de kwaliteit van het milieu. In samenwerking met de leden organiseert of ondersteunt het sectiebestuur symposia en workshops om deze doelstelling te bereiken. Het sectiebestuur volgt activiteiten van internationale organisaties als SETAC en SECOTOX op de voet, en draagt zo nodig bij aan (deel)activiteiten.

Sinds 2006 vergadert en opereert het bestuur samen met het bestuur van de sectie Milieuchemie van de Koninklijke Nederlandse Chemische Vereniging (KNCV). Deze samenwerking bevalt uitermate goed en zal daarom worden gecontinueerd. Het gezamenlijke bestuur kan daarmee worden gezien als één bestuur. Het bestuur staat altijd open voor suggesties van haar leden voor onderwerpen voor workshops, excursies, studiedagen, symposia.

Werkgebied van de sectie Milieutoxicologie

De cyclus van giftige stoffen in het milieu en de mogelijke effecten van deze stoffen op flora en fauna vormen het werkgebied van de milieutoxicologie. Daarbij richt men niet alleen de aandacht op afzonderlijke organismen, maar tracht men binnen dit werkgebied inzicht te krijgen in het voortbestaan van ecosystemen, levensgemeenschappen van verschillende soorten planten en dieren in samenhang met hun omgeving. De milieutoxicologie onderzoekt hoe stoffen worden gedistribueerd over water, bodem en lucht, hun eventuele omzetting in andere stoffen, de manier waarop stoffen een levensgemeenschap binnenkomen en verlaten, hoe zij via voedsel doorgegeven worden, en wat daarvan de gevolgen zijn voor het voortbestaan van levensgemeenschappen. Voorspellingen over de risico's van bepaalde stoffen voor het milieu vormen daarbij het uiteindelijke doel.


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